منابع مشابه
Amyloid imaging in dementia: contribution or confusion?
There is mounting evidence and enthusiasm for molecular imaging contribution to the diagnosis of neurodegenerative dementia. A key advance in the imaging field has been the development of selective ligands that can reveal the presence of pathologic deposition of Aβ-amyloid in the cerebral cortex, consistent with dementia due to Alzheimer disease (AD) or a related neurodegeneration [1]. Recently...
متن کاملAmyloid imaging for dementia in clinical practice
In vivo imaging of brain amyloid using positron emission tomography (PET) scanning is widely used in research studies of dementia, with three amyloid PET ligands being licenced for clinical use. The main clinical use of PET is to help confirm or exclude the likely diagnosis of Alzheimer's disease in challenging cases, where diagnostic uncertainty remains after current clinical and investigative...
متن کاملBeta-amyloid imaging with florbetaben
Florbetaben is a fluorine-18 (18F)-labeled stilbene derivative that was developed as a positron emission tomography (PET) tracer for routine clinical application to visualize β-amyloid plaques in the Alzheimer's disease (AD) brain. The tracer successfully completed a global multicenter phase 0-III development program and was, as a consequence, recently approved by the US Food and Drug Administr...
متن کاملStriatal beta-amyloid deposition in Parkinson disease with dementia.
Dementia is common in Parkinson disease (PD), although its anatomic and pathologic substrates remain undefined. Recently, striatal abnormalities in Lewy body diseases have been described, but their clinical relevance is not clear. Thirty PD cases from the United Kingdom Parkinson's Disease Society Tissue Bank were grouped as demented (PDD; n = 16) and nondemented (PD; n = 14) based on a review ...
متن کاملAmyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo
Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography (PET) with (11)carbon-labelled Pittsburgh Compound-B ((11)C-PIB), the most extensively studied and best validated tracer. PIB binds specifically...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Yeungnam University Journal of Medicine
سال: 2018
ISSN: 2384-0293
DOI: 10.12701/yujm.2018.35.1.1